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January  2022 – New Breakthrough

Scientist Discover The Real Root Cause of Your Belly Fat

(Hint Not Diet or Exercise)

Are you struggling to lose weight no matter how much you diet or exercise?
Turns out, it’s not your fault.

A 2022 study published in Nature Medicine of 52,000 women, and men, the largest of its kind in humans, found just one common factor in every overweight man and woman. Low brown adipose tissue levels! They found common in every skinny person were high brown adipose tissue level. 1

Brown adipose tissue (BAT) also know as brown fat, is not fat at all. Its not a fat storer but a fat shrinker. Its brown color comes from its densely packed mitochondria which work 24/7 to burn calories from your fat stores and the food you eat into pure, natural energy.

Even though BAT makes up a fraction of your weight, it can burn up to 300 times more calories than any other cell in your body! 2

References:
1.https://www.nature.com/articles/s41591-020-1126-7

2.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768171/

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Scientific References:

1. Thomas SS, Kim M, Lee SJ, Cha YS. Antiobesity Effects of Purple Perilla (Perilla frutescens var.
acuta) on Adipocyte Differentiation. J Food Sci. 2018;83(9):2384-2393. doi:10.1111/1750
3841.14288

2. Zhang X, Zhang QX, Wang X, et al. Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1a pathway-mediated mechanism. Int J Obes (Lond). 2016;40(12):1841
1849. doi:10.1038/ijo.2016.108

3. Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, Propolis, and Royal Jelly: A
Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longer.
2017,2017:1259510. doi:10.1155/2017/1259510

4. Zhou SS, Auyeung KK, Yip KM, et al. Stronger anti-obesity effect of white ginseng over red ginseng
and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota. Phytomedicine2020,74:152761. doi:10.1016/j.phymed.2018.11.021

5. Mu Q, Fang X, Li X, et al. Ginsenoside Rb1 promotes browning through regulation of PPARy in 3T3
L1 adipocytes. Biochem Biophys Res Commun. 2015;466(3):530-535.
doi:10.1016/j.bbrc.2015.09.064

6. Kamiya T, Nagamine R, Sameshima-Kamiya M, Tsubata M, Ikeguchi M, Takagaki K. The isoflavone
rich fraction of the crude extract of the Puerariae flower increases oxygen consumption and BAT UCP1 expression in high-fat diet-fed mice. Glob J Health Sci. 2012:4(5):147-155. Published 2012
Aug 12. doi:10.5539/gjhs.v4n5p147

7. Kamiya T, Takano A, Matsuzuka Y, et al. Consumption of Pueraria flower extract reduces body
mass index via a decrease in the visceral fat area in obese humans. Biosci Biotechnol Biochem. 2012;76(8):1511-1517. doi:10.1271/bbb.120235

8. Xu JH, Liu XZ, Pan W, Zou DJ. Berberine protects against diet-induced obesity through regulating
metabolic endotoxemia and gut hormone levels. Mol Med Rep. 2017,15(5):2765-2787.
doi:10.3892/mm.2017.6321

9. Wu L, Xia M, Duan Y, et al. Berberine promotes the recruitment and activation of brown adipose
tissue in mice and humans. Cell Death Dis. 2019;10(6):468. Published 2019 Jun 13.
doi:10.1038/s41419-019-1706-Y

10. Kunkel SD, Elmore CJ, Bongers KS, et al. Ursolic acid increases skeletal muscle and brown fat and
decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One.
2012;7(6):139332. doi:10.1371/journal.pone.0039332

11. Jung YC, Kim HW, Min BK, et al. Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet
induced Mice. In Vivo 2019;33(3):707-715. doi:10.21873/invivo. 11529

12. Oi-Kano Y, Kawada T, Watanabe T, et al. Oleuropein, a phenolic compound in extra virgin olive oil,
increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo). 2008;54(5):363-370.
doi:10.3177/jnsv. 54.363

13. Sohn EJ, Kim JM, Kang SH, et al. Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular
Senescent Human Dermal Fibroblasts. Am J Chin Med. 2018;46(4):853-873.
doi:10.1142/S0192415X18500453

14. Arias N, Picó C, Teresa Macarulla M, et al. A combination of resveratrol and quercetin induces
browning in white adipose tissue of rats fed an obesogenic diet. Obesity (Silver Spring). 2017;25(1):111-121. doi:10.1002/oby.21706

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